Mutagenesis – There are several published reports on the potential genetic toxicity of methadone. Methadone tested negative rein tests for chromosome breakage and disjunction and sex-linked recessive lethal gene mutations rein germ cells of Drosophila using feeding and injection procedures.
The use of methadone hinein patients already known to have a prolonged QT interval has not been systematically studied.
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’Bezeichnung für eine antwort im email-verkehr having a medical emergency. Serious side effects and their symptoms can include the following:
Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result in toxic effects.
Below is a Hinterlist of medications that can interact with methadone. This Trick doesn’t contain all drugs that may interact with X drug.
Methadone hydrochloride is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most namhaft of which involves the central nervous Gebilde and organs composed of smooth muscle.
If you take too much: You could have dangerous levels of the drug hinein your body. Symptoms of an overdose of this drug can include:
For people with a gastrointestinal (Us-soldat) obstruction: This drug can cause constipation and increase your risk of a GI obstruction. If you have a history of GI obstructions or you currently have one, you should talk to your doctor about whether this drug is safe for you.
For seniors: The kidneys of older adults may Methadontabletten ohne Rezept online not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays rein your body for a longer time. This raises your risk of side effects.
Laxatives. Taking these drugs together can change your electrolyte levels. This can cause heart rhythm problems.
The chance is higher if you are or have been addicted to or abused other medicines, street drugs, or alcohol, or if you have a history of mental problems.
For people with seizures: This drug may cause more seizures rein people with epilepsy. If your seizure control gets worse while taking this drug, call your doctor.
Desipramine – Blood levels of desipramine have increased with concurrent methadone administration.
Das liegt zum einen daran, dass die Dosis sukzessive reduziert und zum anderen die psychische Abhängigkeit überwunden werden bedingung. Insgesamt zum erliegen kommen die psychischen Entzugssymptome zumal das Suchtverlangen deutlich länger an denn die physischen, die ihren Höhepunkt bereits nach 2 solange bis 3 Tagen erreichen.